Remember11 takes place in 2011 and 2012 concurrently, from January 11 to January 17, in two places in Japan: an emergency cabin on Mount Akakura in the Hakkōda mountain range, and the Specified Psychiatric Hospital for Isolation and Aegis (SPHIA) institution on the fictional island of Aosagi, in which mentally ill criminals are treated. The player takes the roles of Fuyukawa Kokoro, a third-year sociology major who is stranded on Akakura after surviving a plane crash, and Satoru Yukidoh, who lives in SPHIA and has lost his memory. Kusuda Yuni, a young boy who survived the plane crash, appears in both the cabin and at SPHIA.
Among other survivors of the plane crash are Mayuzumi Lin, a lawyer and the girlfriend of Satoru; and Yomogi Seiji, a professional mountain hiker. The player also encounters two characters at SPHIA: Utsumi Kali, an elementary school teacher who is employed at SPHIA as a psychologist; and a girl assumed to have dissociative identity disorder, who has been confined at SPHIA since being acquitted of murder charges on grounds of insanity. While her birth records identify her as Inubushi Keiko, she claims to not recognize that name, and that her real name is "Suzukage Hotori"; this is the name of one of the passengers on the crashed plane.